OK, they didn’t.
said they were tryin to get enough money for hot dogs.
So I gave em the money for hotdogs.
;_; I can’t say no.
cleaned my office desk
“Although few etiologic factors for brain tumors have been identified, limited data suggest that lead may increase the risk of brain tumors, particularly meningioma. The ALAD G177C polymorphism affects the toxicokinetics of lead and may confer genetic susceptibility to adverse effects of lead exposure.”
http://www.ncbi.nlm.nih.gov/pubmed/17164378
What’s the difference between risk and susceptibility here?
I’m confused.
So risk is like. the risk of getting a disease.
and susceptibility is
um
means that the guh its easier for you to be put at risk
!?
CDCV vs CDRV
Although it may seem paradoxical that deleterious alleles reach high frequency in a population many complex disorders have a late age of onset and thus might not have been subject to strong purifying selection
the CDRV hypothesis, posites that many genes/alleles with lower frequency, higher-penetrance vatiants contribute to diseases
P. argued that the CDRV hypothesis is more consistent with human pathology and population biology than CDCV
linkage studies are well-powered to detect variants with large effects and high penetrance, but are underpowered for detection of variants of small effect
in contrast to linkage analyses association analyses test fora relationship between phenotypes and genotypes in large samples of unrelated individuals, assuming identity by state, where individuals of similar phenotype are assumed to share the same risk variants
genetic differences between populations of different ancestry are modest:ancient polymorphisms that predate this migration are shared bu all human populations and account for approx 90% of human variants
news for you: http://www.gamespot.com/news/xbox-360-banned-in-germany-says-judge-6374678
Keep your eye on this, it seems entertaining.
BABY MANATEE.
Oh I want one of my very own.
Source: http://cuteoverload.com/2012/04/16/oh-the-tree-hugged-manatee/
Tomorrow:
1.) Penetrance vs Risk vs Susceptibility.
Penetrance is the % of people who have the phenotype given a specific genotype.
Risk is “in familiy studies the relative risk of disease in a relative of an affected person, compared to a member of the general population” HMG
“The quantitative or qualitative assessment of an individual’s risk of carrying a certain gene mutation, or developing a particular disorder, or of having a child with a certain disorder; sometimes done by using mathematical or statistical models incorporating such factors as personal health history, family medical history and ethnic background” NCI
Susceptibility is some genotype that increases the likelihood that you suffer form a disease. It generally doesn’t cause the phenotype on its own.
Penetrance = given genoetype, phenotype?
Risk = given family, genotype?
Susceptibility = given genotype, more likely to get phenotype?
